Application of electrical stimulation for peripheral nerve regeneration: Stimulation parameters and future horizons

Peripheral nerve trauma impacts both social and occupational quality of life. Patients are typically young subsequently suffer from lifelong disability. Unlike the central nervous system, peripheral system has capacity to regenerate along previous or new connections. Yet, complete functional recovery been an elusive clinical objective despite development advanced microsurgical techniques repair nerves. In recent decades significant amount work expanded focus towards establishing facets adjuvant treatment improve regeneration. One potential therapy is application electric stimulation nerves immediately following repair. Mounting pre-clinical evidence demonstrated efficacy electrical in improving regeneration recovery. this paper, we review therapeutic benefits current limitations after injury. We also summarize proposed mechanisms increasing regenerative nerves, including human trials. Finally, discuss parameters safety profiles with eye future strategies. Combining conductive scaffolds successful may have profound implications injury patients.